PHYS THER
Vol. 89, No. 10, October 2009, pp. 1099-1100
DOI: 10.2522/ptj.2009.89.10.1099
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Because this article has no abstract, we have provided an extract of the full text and any section headings.

Allison1 writes to defend the use of single-arm trials to investigate treatment effect modification. This position, in our view, is not defensible. The effect of treatment is the difference between outcomes with and without treatment. A single-arm trial cannot provide information about outcomes without treatment, so it cannot quantify the effect of treatment. Therefore, single-arm trials cannot quantify treatment effect modification. In our opinion, much of the confusion with regard to clinical prediction rules (CPRs) for physical therapy intervention has arisen . . . [Full Text of this Article]

Mark Hancock, Rob Herbert and Christopher G. Maher

M. Hancock, PT, PhD, is Lecturer, Back Pain Research Group, The University of Sydney, Sydney, New South Wales, Australia
R. Herbert PT, PhD, is Senior Research Fellow, The George Institute for International Health, The University of Sydney.
C.G. Maher, PT, PhD, is Director, The George Institute for International Health, The University of Sydney.


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